16. Human Disease

Q- The transmission of characters from one generation to next is called
(a) Evolution
(b) Heredity
(c) Genetics
(d) Mutation
Ans: (b)

Q- Who got Noble prize for artificial synthesis of DNA?
(a) M. Calvin (b) Khurana
(c) Tatum (d) Kornberg
Ans: (d)

Q- Which one of the following techniques can be used to establish the paternity of a child?
(a) Protein analysis
(b) Quantitative analysis of DNA
(c) Chromosome counting
(d) DNA finger printing
Ans: (d)

Q- Which one is correctly matched?
(a) Down syndrome : 44 autosome + XO
(b) Klinfelter’s syndrome-44 autosomes + XXY
(c) Erythroblastosis foetalis-X linked
(d) Colour blindness-Y linked
Ans: (b)

Q- Circular DNA is present in
(a) E.R. and Ribosomes
(b) Ribosomes and chloroplasts
(c) Ribosomes and mitochondria
(d) Mitochondria and chloroplasts
Ans: (d)

Q- Which of the following is excellent resource of protein for human body?
(a) Cashew
(b) Almond
(c) Both (a) and (b)
(d) None of the above
Ans: (c)

Q- Mendal worked on
(a) Edible pea (b) Wild pea
(c) Garden pea (d) Pegion Pea
Ans: (c)

Q- A person with blood group A possesses
(a) Antigen A and antibody B
(b) Antigen B and antibody A
(c) Antigen A and antibody B
(d) No antigen and no antibody
Ans: (c)

Q- Which one of following is a sex linked disease?
(a) Leprosy (b) Tuberculosis
(c) Colour blindness
(d) Leukamea
Ans: (c)

Q- Which one of the following is a hereditary disease?
(a) Cataract (b) Haemophilia
(c) Pellagra (d) Osteoporosis
Ans: (b)

Q- The process of transfer of genetic information from DNA to RNA or formation of RNA from DNA is
(a) Transversion
(b) Transcription
(c) Translation
(d) Translocation
Ans: (b)

Q- Gregor Johann Mendel is famous for
(a) Cell theory
(b) Mutation principle
(c) Law of heredity
(d) Heredity of acquired characters
Ans: (c)

Q- Gene are made up of
(a) DNA
(b) RNA
(c) DNA and RNA
(d) Protein
Ans: (a)

Q- Sexual reproduction causes genetic variation because of
(a) Blending of genes
(b) Chromosomal changes
(c) Shuffling of genes
(d) All of the above
Ans: (d)

Q- A colour blind person marry with a normal woman, blindness is produced in their
(a) Son
(b) Daughter
(c) Son of their son
(d) Daughter of their daughter
Ans: (d)

Q- Smallest part of DNA that undergoes recombination is
(a) Muton (b) Cistron
(c) Replicon (d) Recon
Ans: (d)

Q- Number of chromosome in a normal human body cell is
(a) 43 (b) 44
(c) 45 (d) 46
Ans: (d)

Q- Which date is known as diabetes day?
(a) 14th February
(b) 14th May
(c) 14th September
(d) 14th November
Ans: (d)

Q- Find out the mismatched.
(a) Klinefelter’s syndrome – XO
(b) Haemophilia – Sex linked
(c) Down’s syndrome – Autosomal aneuploidy
(d) Turner’s syndrome – female with retarted sexual development
Ans: (a)

Q- Hybridoma technology is a new biotechnological approach for commercial production of
(a) Monoclonal antibodies
(b) Interferon
(c) Antibiotics
(d) Alcohol
Ans: (a)

Q- Mendel’s principles of inheritance are based on
(a) Vegetative reproduction
(b) Asexual reproduction
(c) Sexual reproduction
(d) All of the above
Ans: (c)

Q- Coded information in nucleic acid depend upon
(a) Arrangement of nucleotides
(b) Position of nucleotides
(c) Number of nucleotides
(d) All of the above
Ans: (a)

Q- Unit of heredity is
(a) Gene
(b) Chromosomes
(c) Chromatin
(d) None of the above
Ans: (a)

Q- Most likely reasons for development of resistance in against pesticides is
(a) Genetic recombination
(b) Acquired heritable change
(c) Random mutation
(d) Directed mutation
Ans: (c)

Q- Differentiation of organs and tissues in a developing organism is associated with
(a) Differential expression of genes
(b) Development mutations
(c) Delation of genes
(d) Lethal mutation
Ans: (a)

Q- Queen Victoria of England was
(a) AIDS patient
(b) Deaf
(c) Haemophiliac
(d) Colour blind
Ans: (c)

Q- Mendel’s second law is the law of
(a) Independent assortment
(b) Segregation
(c) Dominance
(d) Polygenic inheritance
Ans: (b)

Q- Nucleotide base present in DNA and not RNA is
(a) Cytosin (b) Uracil
(c) Thymine (d) Guanine
Ans: (c)

Q- For a colour blind person red colour appears as
(a) Yellow (b) Blue
(c) Green (d) Violet
Ans: (c)

Q- DNA strand have
(a) Quaternary structure
(b) Same polarity
(c) Antiparallel polarity
(d) Disulphide bond
Ans: (c)

Q- In genetic dictionary there are 64 codons as
(a) 64 amino acids are to be coded
(b) 64 types of t-RNA are present
(c) There are 44 nonsense codons and 20 sense codons
(d) Genetic code is triplet
Ans: (d)

Q- One gene one enzyme theory is given by
(a) Watson and Crick
(b) Hargovind Khurana
(c) Beadle and Tatum
(d) Morgan
Ans: (c)

Q- Chromosomes are best seen in
(a) Interphase (b) Prophase
(c) Metaphase (d) Telophase
Ans: (c)

Q- Artificial gene synthesis was first done in laboratory by
(a) Millar (b) Khurana
(c) D. Veries (d) Kelvin
Ans: (b)

Q- RNA contains
(a) Hexose (b) Ribose
(c) Fructose (d) Glucose
Ans: (b)

Q- Which type of DNA is found in bacteria?
(a) Straight DNA
(b) Helical DNA
(c) Circular DNA
(d) Membrane – bound DNA
Ans: (c)

Q- Insect resistant cotton plant have been genetically engineered by inserting a gene from a
(a) Virus (b) Bacterium
(c) Insect (d) Plant
Ans: (b)

Q- Genetics deals with
(a) Mendel’s laws
(b) Organic evolution
(c) DNA structure
(d) Heredity and variation
Ans: (d)

Q- Three law of heredity given by Mendel relate
(a) Gene linkage, Segregation and Independent assortments
(b) Gene linkage, Dominance and segregation
(c) Segregation, Independent assortments and dominance
(d) Segregation, Independent assortments and gene linkage
Ans: (c)

Q- Genes located on mitochondrial DNA
(a) Generally show maternal inheritance
(b) Are always inherited from male parent
(c) Show hipa rental inheritance
(d) Are not inherited like the nuclear gene
Ans: (a)

Q- DNA molecule has small units called
(a) Purines
(b) Adenine and thymine
(c) Cistron, muton and reco
(d) Adenine
Ans: (c)

Q- Heredity characters of parent is transfered to their offspring by
(a) Blood
(b) Hormone
(c) Chromosomes
(d) None of the above
Ans: (c)

Q- Nucleic acids are made of
(a) Nucleotides (b) Nucleosides
(c) Amino acids (d) Protein
Ans: (a)

Q- When one gene controls two or more different characters simultaneously, the phenomena is called
(a) Apomixis (b) Pleiotropy
(c) Palyploidy (d) Palyteny
Ans: (b)

Q- Gene located at the same locus but having different expression are
(a) Multiple alleles
(b) Oncogenes
(c) Polygenes
(d) Codominants
Ans: (a)

Q- Who is the father of Genetics?
(a) Darwin (b) Mendel
(c) Bridge (d) Wiseman
Ans: (b)

Q- Experimental evidence to show that the genetic code is a triplet code was provided by
(a) George Gamow
(b) Watson & Crick
(c) Nirenberg and Matthaei
(d) None of the above
Ans: (c)

Q- Genes are situated on
(a) Chromosome(b) Mitochondria
(c) Plastids (d) Ribosomes
Ans: (a)

Q- Daughter born to haemophiliac father and normal mother could be
(a) Normal (b) Carrier
(c) Haemophiliac
(d) All of the above
Ans: (b)

Q- Double helix model of DNA is given by
(a) Leewenhoek
(b) Salach
(c) Watson and Crick
(d) Dalton
Ans: (c)

Q- Monohybrid ratio of Mendel’s cross is
(a) 4 : 1 (b) 3 : 1
(c) 1 : 1 (d) 2 : 1
Ans: (b)

Q- Which one among the following is not correct about Down’s Syndrome?
(a) It is a genetic disorder
(b) Effected individual has early ageing
(c) Effected person has mental retardation
(d) Effected person has furrowed tongue
Ans: (b)

Q- Deficiency of fluoride leads to which one of the following health problem?
(a) Tooth caries
(b) Mottling of tooth
(c) Bending of bones
(d) Stiffening of joints
Ans: (b)

Q- Which one of the following genetic disease is sex-linked ?
(a) Royal haemophilia
(b) Tay-sachs disease
(c) Cystic fibrosis
(d) Hypertension
Ans: (a)

Q- Mendel’s law apply only when
(a) characters are linked
(b) parents are pure breeding
(c) monohybrid ratio shows two types of individuals
(d) first pair of contrasting characters is dependent upon other pairs
Ans: (b)

Q- Genetic identity of human male is known by
(a) Nucleolus (b) Cell organelles
(c) Autosomes
(d) Sex chromosomes
Ans: (d)

Q- Nucleic acid occurs in
(a) Viruses (b) Bacteria
(c) Mammal (d) All form of life
Ans: (d)

Q- Mendel’s law were rediscovered by
(a) Correns (b) Tshermak
(c) Devaries (d) All of these
Ans: (d)

Q- Deploid number of chromosome in man is
(a) 23 (b) 24
(c) 46
(d) Indefinite number
Ans: (a)

Q- Nucleosome contains
(a) Only histones
(b) Both DNA and histones
(c) Only DNA
(d) Both DNA and RNA
Ans: (b)

Q- All offspring of a parents are not similar due to
(a) Variation
(b) Variation in environment
(c) Both (a) and (b)
(d) None of the above
Ans: (c)

Q- Mendel select pea plant for his experiment because
(a) They are cheaper
(b) These are easily available
(c) These are of great economic importance
(d) They have contrasting fraits
Ans: (d)

Q- Mendel’s law of independent assortment is based on ratio of
(a) 1 : 2 : 1 (b) 9 : 3 : 3 : 1
(c) 2 : 1 (d) 3 : 1
Ans: (b)

Q- Who proved that DNA is the basic genetic material?
(a) Griffith
(b) Watson
(c) Boveri and Sutton
(d) Hershey and Chase
Ans: (d)

Q- An exception to Mendel’s principles/ Mendel did not include in his discoveries.
(a) Dominance
(b) Purity of gametes
(c) Linkage
(d) Independent assortment
Ans: (c)

Q- In the context of genetic disorders, consider the following: A woman suffers from colour blindness while her husband does not suffer from it. They have a son and a daughter. In this context, which one of the following statements is most probably correct?
(a) Both children suffer from colour blindness
(b) Daughter suffers from colour blindness while son does not suffer from it
(c) Both children do not suffer from colour blindness
(d) Son suffers from colour blindness while daughter does not suffer from it
Ans: (d)

Q- Sex chromosome in human male are named
(a) XX (b) XO
(c) XY
(d) None of the above
Ans: (c)

Q- A colour blind person cannot distinguish
(a) Black and yellow
(b) Red and green
(c) Yellow and white
(d) Green and blue
Ans: (b)

Q- In humans, height shows a lot of variation. It is an example of
(a) Multiple alleles
(b) Pleiotropic inheritance
(c) Polygenic inheritance
(d) Pseudoalleles
Ans: (c)

Q- Which one of the following is wrongly matched?
(a) Adenine, Thymine – Purines
(b) Thymine, Uracil – Pyrimidines
(c) Uracil, Cytosine – Pyrimidines
(d) Guanine, Adenine – Purines
Ans: (a)

Q- Which one is exception to Mendel’s principle of dominance?
(a) Wild pea (b) Mirabilis
(c) Garden pea (d) Maize
Ans: (b)

Q- Which one of the following is not a genetic disease in human beings?
(a) Huntington’s chorea
(b) Phenylketonuria
(c) Rheumatic heart disease
(d) Tay-Sach’s disease
Ans: (c)

Q- By which combination of chromosome a child will be male?
(a) X from male and X from female
(b) X from male and Y from female
(c) Y from male and X from female
(d) Y from male and Y from female
Ans: (c)

Q- Synthesis of DNA is called
(a) Replication
(b) Transcription
(c) Termination
(d) Amination
Ans: (a)

Q- Haemophilia is due to
(a) Dominant autosomal genes
(b) Recessive autosomal genes
(c) Recessive sex linked genes
(d) Dominant sex linked gene
Ans: (c)

Q- Who is responsible for the sex determination of a child?
(a) Father
(b) Mother
(c) Both mother and father
(d) Non of the above
Ans: (a)

Q- A child is male when
(a) Child have XXYY chromosome
(b) Child have YY chromosome
(c) Child have XY chromosomes
(d) Child have XX Chromosomes
Ans: (c)

Q- Genetic code is a
(a) Singlet
(b) Doublet
(c) Triplet
(d) None of the above
Ans: (c)

Q- Human beings have
(a) 23 pairs of chromosomes
(b) 24 pairs of chromosomes
(c) 25 pairs of chromosomes
(d) 26 pairs of chromosomes
Ans: (a)

Q- The first cloned animal Dolly was a
(a) Dog (b) Rabbit
(c) Cat (d) Sheep
Ans: (d)

Q- Haemophilia is a genetic disorder which lead to
(a) Decrease in haemoglobin level
(b) Rheumatic heart disease
(c) Decrease in WBC
(d) Non-clotting of blood
Ans: (b)

Q- Colour-blindness is related with a defect in
(a) Rod cells (b) Cone cells
(c) Eye muscles (d) All of these
Ans: (b)

Q- Characters are transferred from parents to progeny through
(a) DNA (b) RNA
(c) Protein (d) Phospholipids
Ans: (a)

Q- Branch of biology which deal with the study of heredity is
(a) Cytology (b) Evolution
(c) Genetics (d) Phisology
Ans: (c)

Q- Number of autosomes in human sperm
(a) 20 pairs (b) 21 pairs
(c) 22 pairs (d) 23 pairs
Ans: (c)

Q- Nucleoside is
(a) Nitrogenous base + Sugar
(b) Nitrogenous base + Sugar + Phosphate
(c) Sugar + Phosphate
(d) Nitrogenous base + Phosphate
Ans: (a)

Q- Which one of the following statements is correct? Cretinism is human disorder which is due to the under secretion of
(a) Adrenalin hormone
(b) Cortisone hormone
(c) Glucagon hormone
(d) Thyroxin hormone
Ans: (d)

Q- Assertion (A) : DNA finger printing has became a powerful tool to establish paternity and identity of criminal in rape and assault cases. Reason (R) : Trace evidences such as hair, saliva and dried semen are adequate for DNA analysis. Codes
(a) Both (A) and (R) are true and (R) is the correct explanation of (A)
(b) Both (A) and (R) are true, but
(R) is not the correct explanation of (A)
(c) (A) is true, but (R) is false
(d) (A) is false, but (R) is true
Ans: (a)

Q- Colour blindness in which all colours are preceived as grey, is termed as
(a) Chromasia
(b) Dichromasia
(c) Monochromasia
(d) All of the above
Ans: (c)

Q- Assertion (A) : In human being the female play a major role in determining the sex of the offspring. Reason (R) : Women have two X-chromosomes. Codes
(a) Both (A) and (R) are true and (R) is the correct explanation of (A)
(b) Both (A) and (R) are true, but
(R) is not a correct explanation of (A)
(c) (A) is true, but (R) is false
(d) (A) is false, but (R) is true
Ans: (d)

Q- Assertion (A) : Insect resistance transgenic cotton has been produced by inserting Bt gene. Reason (R) : The Bt gene is derived from a bacterium. Codes
(a) Both (A) and (R) are true and (R) is the correct explanation of (A)
(b) Both (A) and (R) are true, but
(R) is not the correct explanation of (A)
(c) (A) is true, but (R) is false
(d) (A) is false, but (R) is true
Ans: (b)

Q- Which of the following professional are more likely to run the risk of a permanent change in their cell’s DNA?
1. Researchers using carbon 14 isotope
2. X-ray technician
3. Coal miner
4. Dyer and painter Codes
(a) Only 2 (b) 1, 2 and 3
(c) 1, 2 and 4 (d) 1, 3 and 4
Ans: (c)

Q- Assertion (A) : Dolly was the first cloned mammal. Reason (R) : Dolly was produced by invitro fertilization. Codes
(a) Both (A) and (R) are true and (R) is the correct explanation of (A)
(b) Both (A) and (R) are true, but
(R) is not the correct explanation of (A)
(c) (A) is true, but (R) is false
(d) (A) is false, but (R) is true
Ans: (d)

Q- Match List-I with List-II and select the correct answer using the codes given below: List-I List-II
A. Discovery of transduction and conjugation
1. Khurana
B. Establishing the sex-linked inheritance
2. Korenberg
C. Isolation of DNA polymerase from E. coli
3. Lederberg
D. Establishing the complete genetic code
4. Morgan Codes A B C D
(a) 4 3 2 1
(b) 3 4 1 5
(c) 4 3 1 5
(d) 3 4 2 1
Ans: (d)

Q- Match List-I with List-II and select the correct answer using the codes given below : List-I List-II
A. Theory of mutation
1. Beadle and Tatum
B. Theory of evolution
2. Jacob and Monod
C. One gene one enzyme hypothesis
3. Darwin
D. Operon concept
4. De Vries Codes A B C D
(a) 3 4 1 2
(b) 4 3 1 2
(c) 4 3 1 2
(d) 3 4 2 1
Ans: (b)

Q- The concept of survival of the fittest as advanced by
(a) Charles Lyell
(b) Charles Darwin
(c) Herbert Spencer
(d) Alfred Russel Wallace
Ans: (c)

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